I've included the keys I have them bound to but you can use whatever.
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Destruction
#1 - shift+alt Summon Doomguard, shift Ember Tap, alt Conflag, Corruption (Immolate)
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#showtooltip
/cast [mod:shift,mod:alt] Summon Doomguard; [mod:shift] Ember Tap; [mod:alt] Conflagrate; Corruption
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/cast [mod:shift,mod:alt] Summon Infernal; [mod:shift] Drain Life; [mod:alt] Chaos Bolt; Shadow Bolt;
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/cast [mod:alt] Fire and Brimstone; Shadowburn;
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/cast [mod:shift] Curse of Enfeeblement; [mod:alt] Havoc; Curse of the Elements
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/cast [mod] Shadowfury; Fel Flame
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/cast [mod] Soulshatter; Twilight Ward
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/cast [mod:ctrl] Potion of the Jade Serpent; [mod:alt] Dark Soul; Rain of Fire