First thing I would grab, if you don't have it already is Process Explorer
it'll let you see which processes are actually running on your machine.
Figure out whats running, boot up in safe mode (if you can) and nuke it.
Viruses like to hide in your system restore so make sure you disable system restore when you're trying to kill this thing.
Delete the hard files, then go through regedit and nuke any trace of the thing.
It's the thought that counts, not how many people die because of it.