It will work with Aion, they just haven't released a game specific addon for anything but wow and warhammer. But you can still set it up to just press 0-9 +3 keys.
In fact, it will probably be even more useful in aion since it focuses more on movement... you fight while flying, so you are moving up and down, not just forward, back, right, left and you get bonuses in fights depending on the direction you move - forward increases your damage, back increases your defense, side to side increases your dodge.
This mouse is designed so you can cast and turn with your right hand and only worry about movement and a possible modifier with your left. It really is brilliant.